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Microsoft addressed a mailbox syncing issue some users are seeing with Exchange Server 2010, suggesting that administrators block or throttle devices running iOS 6.1 until the problem is fixed.



From Apple Insider:
According to the online document, the issue arises when Exchange clients attempt to sync a device running Apple's latest iOS 6.1 mobile operating system with Microsoft Exchange Server 2010, causing excessive log growth that affects the server's performance. Microsoft notes that it is currently working with Apple to fix the problem.

Users of the latest Office 365 Online Exchange were also affected, and began receiving error messages reading "Cannot Get Mail" and "The connection to the server failed" when attempting to access the service from an iOS 6.1-based device.
  Microsoft recommends blocking iOS 6.1 users due to Exchange Server issue